Stability Indicating RP-HPLC Method for Simultaneous Determination of Simvastatin and Ezetimibe from Tablet Dosage Form
نویسندگان
چکیده
منابع مشابه
Stability Indicating RP-HPLC Method for Simultaneous Determination of Simvastatin and Ezetimibe from Tablet Dosage Form
A simple, specific and sensitive reverse phase high performance liquid chromatographic method was developed and validated for simultaneous determination of ezetimibe and simvastatin from pharmaceutical dosage forms. The method uses C18 ODS Hypersil column and isocratic elution. The mobile phase composed of acetonitrile:phosphate buffer (pH 4.5, 0.01M) in the ratio of 65:35 v/v was used at a flo...
متن کاملStability Indicating Rp-hplc Method for Simultaneous Determination of Aspirin and Clopidogrel in Dosage Form
Stability-indicating High Performance Liquid Chromatographic (HPLC) method was developed for simultaneous Aspirin and Clopidogrel, A Phenomenex Gemini C-18, 5 μm column having 250mm x 4.6 mm i.d. in isocratic mode, with mobile phase containing buffer solution 0.3% orthophosphoric acid : acetonitrile (65: 35, v/v). The flow rate was 1 ml/min and effluents were monitored at 266 nm. For linearity ...
متن کاملStability Indicating Rp-hplc Method for Simultaneous Determination of Frusemide and Amiloride Hydrochloride in Tablet Dosage Form
This article focuses on stability indicating RP-HPLC method for simultaneous estimation of Frusemide and Amiloride Hydrochloride as API and in tablet dosage form, validation of developed method and its application in pharmaceutical companies. Acetonitrile, potassium di hydrogen phosphate and phosphoric acid were used. Chromatographic conditions comprised of C18 column (250 × 4.6 mm, 5 μm), mobi...
متن کاملSimultaneous Determination of Metformin and Vildagliptin in Solid Dosage Form by Stability Indicating Rp-hplc Method
A simple, precise and rapid HPLC method has been developed for the simultaneous determination of Metformin and Vildagliptin in pharmaceutical dosage form. The method was carried out using Sunfire BDS C8 column (250 mm x 4.6 mm, 5 μm) and mobile phase comprised of disodium hydrogen phosphate pH 7.0±0.05 as buffer and acetonitrile in the ratio of 60:40 v/v and degassed under ultrasonication. The ...
متن کاملGradient Stability Indicating RP-HPLC Method for Impurity Profiling of Simvastatin in Tablet Dosage Forms
Gradient, reversed phase high performance liquid chromatographic (RP-HPLC) method was developed for quantitative estimation and validation of simvastatin impurities which are generated during formulation and storage of simvastatin in tablet dosage forms. The chromatographic separation was achieved on column intersil ODS (150 mm × 4.6 mm, 5 μm) by following gradient flow using mobile phase A and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2010
ISSN: 0250-474X
DOI: 10.4103/0250-474x.65028